IUPAC name
Other names
  • 1118-68-9
  • 653
ECHA InfoCard100.012.971
EC Number
  • 214-267-8
  • C01026
RTECS number
CompTox Dashboard(EPA)
  • InChI=1S/C4H9NO2/c1-5(2)3-4(6)7/h3H2,1-2H3,(H,6,7)
  • CN(C)CC(O)=O
Molar mass103.121 g·mol−1
AppearanceWhite crystals
Density1.069 g/mL
Melting point 178 to 182 °C (352 to 360 °F; 451 to 455 K)
Boiling point 175.2 °C (347.4 °F; 448.3 K)
GHS pictograms
GHS Signal wordWarning
Lethal dose or concentration (LD, LC):
>650 mg kg−1(oral, rat)
Related compounds
Related alkanoic acids
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
verify (what is ?)
Infobox references

Dimethylglycine (DMG) is a derivative of the amino acidglycine with the structural formula (CH3)2NCH2COOH. It can be found in beans and liver. It can be formed from trimethylglycine upon the loss of one of its methyl groups. It is also a byproduct of the metabolism of choline.

When DMG was first discovered, it was referred to as Vitamin B16, but, unlike true B vitamins, deficiency of DMG in the diet does not lead to any ill-effects and it is synthesized by the human body in the citric acid (or Krebs) cycle meaning it does not meet the definition of a vitamin.

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What is N,N-Dimethylglycine (DMG)? N,N-Dimethylglycine is a tertiary amino acid, the dimethylated derivative of glycine, and is a natural component of animal and plant metabolism. In the body, DMG is produced in the one-carbon transfer cycle from choline via betaine in an enzyme controlled transmethylation reaction. Dimethylglycine (DMG) is a versatile, health-building, anti-aging and healing nutrient derived from the amino acid Glycine. It is very important for optimal health and is produced by all animals and humans in small amounts.


Dimethylglycine has been suggested for use as an athletic performance enhancer, immunostimulant, and a treatment for autism, epilepsy, or mitochondrial disease.[2] There is no evidence that dimethylglycine is effective for treating mitochondrial disease.[3] Published studies on the subject have shown little to no difference between DMG treatment and placebo in autism spectrum disorders.[4][5]

Problems mounting leopard as dmg ubuntu For example, a dmg on a friend's machine, copied to my machine, shows asVAX COFF executable not stripped - version 376Ok, after loooking at that page, it came back to me, and I just tested it.If it's a dmg that is a block type device, that is if file dmg showsMacintosh HFS Extended version 4 data (and maybe some other things),It can be mounted, assuming the hfsplus module is present withmount -o loop. I'm trying to remember how I did this. I think I ran mkisofs on the dmg and then did mount -o loop.isoEither that or I gave up and did it on a VM running a system with a newer kernel.Also, take a look at thisthe system won't see it as a block device.

Biological activity[edit]

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Dimethylglycine has been found to act as an agonist of the glycine site of the NMDA receptor.[6]


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This compound is commercially available as the free form amino acid, and as the hydrochloride salt [2491-06-7 ]. DMG may be prepared by the alkylation of glycine via the Eschweiler–Clarke reaction. In this reaction, glycine is treated with aqueous formaldehyde in formic acid that serves as both solvent and reductant. Hydrochloric acid is added thereafter to give the hydrochloride salt. The free amino acid may have been obtained by neutralization of the acid salt, which has been performed with silver oxide.[7]

H2NCH2COOH + 2 CH2O + 2 HCOOH → (CH3)2NCH2COOH + 2 CO2 + 2 H2O


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  1. ^'dimethylglycine - Compound Summary'. PubChem Compound. USA: National Center for Biotechnology Information. 16 September 2004. Identification. Retrieved 24 April 2012.
  2. ^'Dimethylglycine'. About Herbs, Botanicals & Other Products. Memorial Sloan–Kettering Cancer Center. December 8, 2009.
  3. ^Pfeffer, Gerald; Majamaa, Kari; Turnbull, Douglass M.; Thorburn, David; Chinnery, Patrick F. (2012-04-18). 'Treatment for mitochondrial disorders'. The Cochrane Database of Systematic Reviews (4): CD004426. doi:10.1002/14651858.CD004426.pub3. ISSN1469-493X. PMID22513923.
  4. ^Bolman WM, Richmond JA (June 1999). 'A double-blind, placebo-controlled, crossover pilot trial of low-dose dimethylglycine in patients with autistic disorder'. Journal of Autism and Developmental Disorders. 29 (3): 191–4. doi:10.1023/A:1023023820671. PMID10425581.
  5. ^Kern JK, Miller VS, Cauller PL, Kendall PR, Mehta PJ, Dodd M (March 2001). 'Effectiveness of N,N-dimethylglycine in autism and pervasive developmental disorder'. Journal of Child Neurology. 16 (3): 169–73. doi:10.1177/088307380101600303. PMID11305684.
  6. ^Lin, Jen-Cheng; Chan, Ming-Huan; Lee, Mei-Yi; Chen, Yi-Chyan; Chen, Hwei-Hsien (2016). 'N,N-dimethylglycine differentially modulates psychotomimetic and antidepressant-like effects of ketamine in mice'. Progress in Neuro-Psychopharmacology and Biological Psychiatry. 71: 7–13. doi:10.1016/j.pnpbp.2016.06.002. ISSN0278-5846. PMID27296677.
  7. ^Clarke, H. T.; Gillespie, H. B.; Weisshaus, S. Z. (1933). 'The Action of Formaldehyde on Amines and Amino Acids'. Journal of the American Chemical Society. 55 (11): 4571. doi:10.1021/ja01338a041.

N N-dimethylglycine Hcl Dmg Powder Reviews

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